THE EFFECT OF THE IMBALANCE OF CELLULAR REGULATORS ON THE FORMATION OF PLACENTAL INSUFFICIENCY IN WOMEN WITH THREATENED MISCARRIAGE IN THE FIRST TRIMESTER

Abstract

Purpose: To study the role of intracellular bioregulators in the formation of placental insufficiency in case of threatened miscarriage in the first trimester.Materials and methods: 106 women were examined. There were 54 women with the threatened miscarriage in the 6th-12th weeks of pregnancy, 52 women with physiological course of gestation. In the blood serum of these women the amount of follistatin, activin A, glycodelin A, TNF-α, IL-1β and VEGF-A were detected by immunoenzyme method.Results: The disturbance of the existing correlation between the studied bioregulators providing the trophoblast invasion was determined.Summary: The imbalance of the indicated regulatory polypeptides results in the change of their interaction causing the disturbance of the ovum nidation and abnormality of the trophoblast invasion that are the bases for formation of placental insufficiency, which creates conditions for the termination of pregnancy.

Keywords

• threatened miscarriage
• placental insufficiency
• intracellular regulators