The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2

Abstract

Neurology: Seeking salvation for spines after surgery Therapeutic strategies that protect neurological function could prevent serious side effects associated with surgery of the aorta. Patients undergoing aortic surgery for aneurysm or other conditions are at risk of spinal cord damage associated with reduced blood flow during surgery and the subsequent restoration of normal circulation. Researchers led by Fei Yin at Jilin University in Changchun, China, have identified molecular mechanisms that can potentially increase this neurological harm. They show that the combination of low oxygen and reperfusion triggers production of a protein called Foxd3, which switches off cellular pathways that otherwise protect and repair vulnerable tissues. By interfering with this Foxd3-mediated response, Yin’s team was able to protect motor function and preserve the survival of spinal cord neurons in a rat model of this condition, suggesting a potential therapeutic avenue for heart surgery patients.