Correlation between glycemic variability and gastroesophageal reflux in adolescentswith type 1 diabetes mellitus

Abstract

Aims. To estimate an impact of glycemic variability on the development of gastroesophageal reflux disease (GERD) in adolescents with type 1 diabetes mellitus (T1DM). Materials and methods. We enrolled 33 patients with T1DM aged from 12 to 17 years. 24-h pH-monitoring was performed with ?Gas- troskan 24? system (Istok-Sistema, Fryazino); 24-h continuous glucose monitoring utilized CGMS MMT-7310 (Medtronic Minimed, USA) with subsequent night-time analysis. Results. As compared to stable night-time glycemia controls (SD 2.0 mmol/L) showed longer period of esophageal acidification (17% [2?58]; p

Keywords

• diabetes mellitus type 1
• adolescents
• glycemic variability
• gastroesophageal reflux