Chromosome arm aneuploidies shape tumour evolution and drug response

Ankit Shukla; Thu H. M. Nguyen; Sarat B. Moka; Jonathan J. Ellis; John P. Grady; Harald Oey; Alexandre S. Cristino; Kum Kum Khanna; Dirk P. Kroese; Lutz Krause; Eloise Dray; J. Lynn Fink; Pascal H. G. Duijf

doi:10.1038/s41467-020-14286-0

Nature Communications (Jan 2020)

Chromosome arm aneuploidies shape tumour evolution and drug response

Ankit Shukla,
Thu H. M. Nguyen,
Sarat B. Moka,
Jonathan J. Ellis,
John P. Grady,
Harald Oey,
Alexandre S. Cristino,
Kum Kum Khanna,
Dirk P. Kroese,
Lutz Krause,
Eloise Dray,
J. Lynn Fink,
Pascal H. G. Duijf

Affiliations

Ankit Shukla: University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
Thu H. M. Nguyen: University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
Sarat B. Moka: School of Mathematics and Physics, The University of Queensland
Jonathan J. Ellis: University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
John P. Grady: University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
Harald Oey: University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
Alexandre S. Cristino: Griffith Institute for Drug Discovery, Griffith University
Kum Kum Khanna: QIMR Berghofer Medical Research Institute
Dirk P. Kroese: School of Mathematics and Physics, The University of Queensland
Lutz Krause: University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
Eloise Dray: Department of Biochemistry and Structural Biology, UT Health San Antonio
J. Lynn Fink: University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute
Pascal H. G. Duijf: University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute

DOI: https://doi.org/10.1038/s41467-020-14286-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Chromosome arm-level aneuploidies (CAAs) are frequently observed in cancer. Here, the authors analyse CAA landscapes across different tumour types, relating these chromosome arm gains and losses to tumour evolution, metastasis, patient survival and response to a range of anti-cancer therapies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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