Bibliometric analysis of global research on the role of apolipoprotein E in Alzheimer's disease
Zhanzhang Wang,
Xiuqing Zhu,
Yuguan Wen,
Dewei Shang
Affiliations
Zhanzhang Wang
Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China
Xiuqing Zhu
Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China
Yuguan Wen
Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China; Corresponding author. Department of Pharmacy, the Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Road, Guangzhou 510370, China.
Dewei Shang
Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China; Corresponding author. Department of Pharmacy, the Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Road, Guangzhou 510370, China.
Alzheimer's disease (AD) has attracted considerable attention from the public and scientific researchers, leading to a rapid growth in relevant research on this disorder in the last 10 years. The present study aimed to conduct a bibliometric analysis to elucidate the trends of global research on the role of apolipoprotein E in AD in the past decade. Three bibliometric software (CiteSpace, VOSviewer, and R Bibliometrix) were used to analyze the active journals, countries/regions, institutes, authors, co-cited references, and keywords in this field. The USA was the most influential country, and the University of California was the most productive institute. Zetterberg H contributed the highest number of publications, and Petersen RC was the most cited author in this field. On the basis of the co-cited reference analysis, knowledge base on biomarkers, risk factors, and mechanisms were updated in the past decade. Current research hotspots are shifting to tau-related mechanisms and identification of genetic risk factors. Our study provides insights into the developing knowledge base and trends related to research on apolipoprotein E in AD, which may provide new directions for further research in this field.
