QUANTITITATIVE CHANGES OF T-REGULATORY CELLS IN PATIENTS WITH POLIPOUS RHINOSINUSITIS TREATED BY NASAL GLUCOCORTICOSTEROIDS

Abstract

Abstract. This work was aimed for studying immunity markers, especially, T-regulatory cells, in patients suffering from polypous rhinosinusitis and treated with nasal steroids, in frame of integrated preventive treatment. The study included fifteen patients of both sexes (18 to 60 years of age), and eighteen persons with difficulties of nasal breathing not associated with inflammatory events. T-regulatory cells were determined by a specific set of membrane receptors (CD4+, CD25+, CD127-). We have shown a significant reduction in T-regulatory cell contents prior to treatment, followed by their increase to normal levels in the course of therapy.

Keywords

• polypous rhinosinusitis
• flow cytometry
• t-regulatory cells
• topical glucocorticoids