5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

A. Gautheron; A. Gautheron; J. D. Bernstock; J. D. Bernstock; T. Picart; T. Picart; J. Guyotat; P. A. Valdés; P. A. Valdés; P. A. Valdés; B. Montcel

doi:10.3389/fnins.2024.1310282

Frontiers in Neuroscience (Jan 2024)

5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

A. Gautheron,
A. Gautheron,
J. D. Bernstock,
J. D. Bernstock,
T. Picart,
T. Picart,
J. Guyotat,
P. A. Valdés,
P. A. Valdés,
P. A. Valdés,
B. Montcel

Affiliations

A. Gautheron: Université Jean Monnet Saint-Etienne, CNRS, Institut d Optique Graduate School, Laboratoire Hubert Curien UMR 5516, Saint-Étienne, France
A. Gautheron: Univ Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1294, Lyon, France
J. D. Bernstock: Department of Neurosurgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States
J. D. Bernstock: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States
T. Picart: Department of Neurosurgical Oncology and Vascular Neurosurgery, Pierre Wertheimer Neurological and Neurosurgical Hospital, Hospices Civils de Lyon, Lyon, France
T. Picart: Université Lyon 1, INSERM 1052, CNRS 5286, Lyon, France
J. Guyotat: Department of Neurosurgical Oncology and Vascular Neurosurgery, Pierre Wertheimer Neurological and Neurosurgical Hospital, Hospices Civils de Lyon, Lyon, France
P. A. Valdés: Department of Neurosurgery, University of Texas Medical Branch, Galveston, TX, United States
P. A. Valdés: Department of Neurobiology, University of Texas Medical Branch, Galveston, TX, United States
P. A. Valdés: Department of Electrical and Computer Engineering, Rice University, Houston, TX, United States
B. Montcel: Univ Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1294, Lyon, France

DOI: https://doi.org/10.3389/fnins.2024.1310282
Journal volume & issue: Vol. 18

Abstract

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The review begins with an overview of the fundamental principles/physics underlying light, fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence spectroscopy methods used in neurosurgery (e.g., intensity, time-resolved) and in so doing, describe their specific features (e.g., hardware requirements, main processing methods) as well as their strengths and limitations. Finally, we review current clinical applications and future directions of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence spectroscopy in neurosurgery.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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Abstract

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