Interspecies Organogenesis for Human Transplantation

Andrew T. Crane; Rajagopal N. Aravalli; Atsushi Asakura; Andrew W. Grande; Venkatramana D. Krishna; Daniel F. Carlson; Maxim C.-J. Cheeran; Georgette Danczyk; James R. Dutton; Perry B. Hackett; Wei-Shou Hu; Ling Li; Wei-Cheng Lu; Zachary D. Miller; Timothy D. O’Brien; Angela Panoskaltsis-Mortari; Ann M. Parr; Clairice Pearce; Mercedes Ruiz-Estevez; Maple Shiao; Christopher J. Sipe; Nikolas G. Toman; Joseph Voth; Hui Xie; Clifford J. Steer; Walter C. Low

doi:10.1177/0963689719845351

Cell Transplantation (Sep 2019)

Interspecies Organogenesis for Human Transplantation

Andrew T. Crane,
Rajagopal N. Aravalli,
Atsushi Asakura,
Andrew W. Grande,
Venkatramana D. Krishna,
Daniel F. Carlson,
Maxim C.-J. Cheeran,
Georgette Danczyk,
James R. Dutton,
Perry B. Hackett,
Wei-Shou Hu,
Ling Li,
Wei-Cheng Lu,
Zachary D. Miller,
Timothy D. O’Brien,
Angela Panoskaltsis-Mortari,
Ann M. Parr,
Clairice Pearce,
Mercedes Ruiz-Estevez,
Maple Shiao,
Christopher J. Sipe,
Nikolas G. Toman,
Joseph Voth,
Hui Xie,
Clifford J. Steer,
Walter C. Low

Affiliations

Andrew T. Crane: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Rajagopal N. Aravalli: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, USA
Atsushi Asakura: Department of Neurology, University of Minnesota, Minneapolis, USA
Andrew W. Grande: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Venkatramana D. Krishna: Department of Veterinary Population Medicine, University of Minnesota, St. Paul, USA
Daniel F. Carlson: Recombinetics, Inc., St. Paul, USA
Maxim C.-J. Cheeran: Department of Veterinary Population Medicine, University of Minnesota, St. Paul, USA
Georgette Danczyk: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
James R. Dutton: Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA
Perry B. Hackett: Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA
Wei-Shou Hu: Department of Chemical Engineering and Material Science, University of Minnesota, Minneapolis, USA
Ling Li: Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, USA
Wei-Cheng Lu: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Zachary D. Miller: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Timothy D. O’Brien: Department of Veterinary Population Medicine, University of Minnesota, St. Paul, USA
Angela Panoskaltsis-Mortari: Department of Pediatrics, University of Minnesota, Minneapolis, USA
Ann M. Parr: Stem Cell Institute, University of Minnesota, Minneapolis, USA
Clairice Pearce: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Mercedes Ruiz-Estevez: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Maple Shiao: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Christopher J. Sipe: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Nikolas G. Toman: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Joseph Voth: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Hui Xie: Department of Neurosurgery, University of Minnesota, Minneapolis, USA
Clifford J. Steer: Department of Medicine, University of Minnesota, Minneapolis, USA
Walter C. Low: Stem Cell Institute, University of Minnesota, Minneapolis, USA

DOI: https://doi.org/10.1177/0963689719845351
Journal volume & issue: Vol. 28

Abstract

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Blastocyst complementation combined with gene editing is an emerging approach in the field of regenerative medicine that could potentially solve the worldwide problem of organ shortages for transplantation. In theory, blastocyst complementation can generate fully functional human organs or tissues, grown within genetically engineered livestock animals. Targeted deletion of a specific gene(s) using gene editing to cause deficiencies in organ development can open a niche for human stem cells to occupy, thus generating human tissues. Within this review, we will focus on the pancreas, liver, heart, kidney, lung, and skeletal muscle, as well as cells of the immune and nervous systems. Within each of these organ systems, we identify and discuss (i) the common causes of organ failure; (ii) the current state of regenerative therapies; and (iii) the candidate genes to knockout and enable specific exogenous organ development via the use of blastocyst complementation. We also highlight some of the current barriers limiting the success of blastocyst complementation.

Published in Cell Transplantation

ISSN: 0963-6897 (Print); 1555-3892 (Online)
Publisher: SAGE Publishing
Country of publisher: United States
LCC subjects: Medicine
Website: http://journals.sagepub.com/home/cll

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