Roles of mTOR in the Regulation of Pancreatic β-Cell Mass and Insulin Secretion

Abstract

Pancreatic β-cells are the only type of cells that can control glycemic levels via insulin secretion. Thus, to explore the mechanisms underlying pancreatic β-cell failure, many reports have clarified the roles of important molecules, such as the mechanistic target of rapamycin (mTOR), which is a central regulator of metabolic and nutrient cues. Studies have uncovered the roles of mTOR in the function of β-cells and the progression of diabetes, and they suggest that mTOR has both positive and negative effects on pancreatic β-cells in the development of diabetes.

Keywords

• mTOR
• pancreatic β-cell
• autophagy
• ER stress
• insulin secretion