DRUG UTILIZATION STUDY ON ANTIMICROBIAL USE IN URINARY TRACT INFECTION

Abstract

Introduction: Antimicrobials are prescribed commonly for urinary tract infection. But if not used rationally then there will be increase chances of resistance of bacteria as well as increase in duration of morbidity and total cost of therapy. This study was conducted to throw light the antimicrobial utilization pattern. Aim: To study and analyze the pattern of antimicrobial utilization in UTI. Method: A descriptive retrospective study was conducted in tertiary care hospital for 6 months. Case sheets diagnosed with UTI were collected from medical records department (MRD). The demographic data and prescription pattern of each case sheet were evaluated. The data obtained was subjected to descriptive statistical analysis using Microsoft excel. Result: Total 108 patients were included in the study, out of which 44.4% were males and 55.6% were females. Most of the patients were in 40-60 years age group (40.7%). UTI confirmed by culture in 59.26% patients; in which E.coli was isolated in 35.9% patients followed by Klebsiella species (14.06%) and Pseudomonas aerugenosa (7.8%). The World Health Organization (WHO) indicators (utilization in defined daily doses (DDD); DDD/1000inhabitant/day) were used and the ATC/DDD method was implemented. The most commonly prescribed antimicrobial was ceftriaxone followed by cefixime and azithromycin. Conclusion: The DDD/1000inhabitant/day of ceftriaxone was the highest (12.9). Third generation cephalosporins were used as first line drug in most cases. This group should be reserved for complicated UTIs.

Keywords

• DDD (defined daily dose)
• WHO indicators
• ceftriaxone
• generic names