A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

Yanzhe Gao; Elizabeth Mutter-Rottmayer; Alicia M. Greenwalt; Dennis Goldfarb; Feng Yan; Yang Yang; Raquel C. Martinez-Chacin; Kenneth H. Pearce; Satoshi Tateishi; Michael B. Major; Cyrus Vaziri

doi:10.1038/ncomms12105

Nature Communications (Jul 2016)

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

Yanzhe Gao,
Elizabeth Mutter-Rottmayer,
Alicia M. Greenwalt,
Dennis Goldfarb,
Feng Yan,
Yang Yang,
Raquel C. Martinez-Chacin,
Kenneth H. Pearce,
Satoshi Tateishi,
Michael B. Major,
Cyrus Vaziri

Affiliations

Yanzhe Gao: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill
Elizabeth Mutter-Rottmayer: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill
Alicia M. Greenwalt: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill
Dennis Goldfarb: Department of Computer Science, University of North Carolina at Chapel Hill
Feng Yan: Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Yang Yang: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill
Raquel C. Martinez-Chacin: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill
Kenneth H. Pearce: Center For Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Satoshi Tateishi: Division of Cell Maintenance, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University
Michael B. Major: Department of Computer Science, University of North Carolina at Chapel Hill
Cyrus Vaziri: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/ncomms12105
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

RAD18 is an important protein in trans-lesion synthesis, an error-prone damage-tolerant mode of DNA replication. Here the authors show that MAGE-A4 stabilizes RAD18 and allows cancer cells to maintain on-going DNA synthesis in the face of genotoxic injury.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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