Pituitary adenoma associated with xanthogranuloma

Diane Armao, MD; Thomas W. Bouldin, MD; Terry S. Hartman, MPH, MS; Brian D. Thorp, MD; Valerie Jewells, DO

Radiology Case Reports (Jun 2023)

Pituitary adenoma associated with xanthogranuloma

Diane Armao, MD,
Thomas W. Bouldin, MD,
Terry S. Hartman, MPH, MS,
Brian D. Thorp, MD,
Valerie Jewells, DO

Affiliations

Diane Armao, MD: Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, 101 Manning Dr, Chapel Hill, NC 27599, USA; Department of Radiology, University of North Carolina School of Medicine, 101 Manning Dr, Chapel Hill, NC 27599, USA; Corresponding author.
Thomas W. Bouldin, MD: Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, 101 Manning Dr, Chapel Hill, NC 27599, USA
Terry S. Hartman, MPH, MS: Department of Radiology, University of North Carolina School of Medicine, 101 Manning Dr, Chapel Hill, NC 27599, USA; Department of Health Informatics, Rutgers University School of Health Professions, 65 Bergen St, Suite 120, Newark, NJ 07107, USA
Brian D. Thorp, MD: Department of Otolaryngology, University of North Carolina School of Medicine, 101 Manning Dr, Chapel Hill, NC 27599, USA
Valerie Jewells, DO: Department of Radiology, University of North Carolina School of Medicine, 101 Manning Dr, Chapel Hill, NC 27599, USA

Journal volume & issue: Vol. 18, no. 6
pp. 2078 – 2080

Abstract

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Xanthogranuloma (XG) of the sellar region is a non-neoplastic inflammatory lesion characterized histologically by recent and remote hemorrhage, necrotic debris, fibrosis, chronic inflammation, and cholesterol clefts with associated foreign-body giant cells. The inflammatory lesion was recognized by the World Health Organization in 2000. XG of the sellar region is rare. Cases of pituitary adenoma (PA) with an associated XG (PA/XG) are extremely rare, with a total of 16 cases in the literature. PA/XG lacks specific clinical and radiologic signs, making pre-operative diagnosis challenging. Herein, we report a case of PA/XG, describe the radiologic and pathologic findings, and discuss the role of so-called silent or “subclinical pituitary apoplexy” in the possible histogenesis of PA/XGs.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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Abstract

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