Кардиоваскулярная терапия и профилактика (Feb 2005)
Lipoprotein(a) and apolipoprotein B as risk factors in coronary heart disease and acute myocardial infarction development
Abstract
Aim. To investigate associations between coronary heart disease (CHD) and levels of lipoprotein(a), Lp(a), apolipoprotein B, apoB, as important risk factors (RF). Material and methods. The study included 661 participants: 575 patients with confirmed CHD (302 males; mean age 63.21±12.1 years; 273 females, mean age 69.57±10.85 years), and 86 individuals without cardiovascular disease (CVD) at baseline (60 males, mean age 37.41±12.26 years; 26 females, mean age 40.53±12.04 years). Lipid profile: total cholesterol (TCH), triglycerides (TG), Lp(a), apoB – was assessed. Results. Significant difference between two groups was observed in t-test: for apoB level p=0.0000; for Lp(a) p=0.0069. Lp(a) and apoB levels correlated with other standard parameters of lipid profile – TCH, TG. ApoB level (mg/dl) was significantly higher in CHD patients with arterial hypertension (AH) than in normotensive patients, as well as in participants with anterior acute myocardial infarction (MI). Conclusion. Lipid profile parameters Lp(a) and apoB are important RF of CHD. Positive correlation between Lp(a) and TCH levels was observed only in CHD patients, in comparison with CVD-free individuals. In CHD patients with normal TCH and TG levels, increased apoB concentration (>120 mg/dl) was an important RF of CHD development, especially in AH individuals. ApoB level increase significantly correlated with acute MI risk (anterior MI, in particular) in CHD patients.
