Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

Ryosuke Kojima; Daniel Bojar; Giorgio Rizzi; Ghislaine Charpin-El Hamri; Marie Daoud El-Baba; Pratik Saxena; Simon Ausländer; Kelly R. Tan; Martin Fussenegger

doi:10.1038/s41467-018-03733-8

Nature Communications (Apr 2018)

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

Ryosuke Kojima,
Daniel Bojar,
Giorgio Rizzi,
Ghislaine Charpin-El Hamri,
Marie Daoud El-Baba,
Pratik Saxena,
Simon Ausländer,
Kelly R. Tan,
Martin Fussenegger

Affiliations

Ryosuke Kojima: ETH Zürich, Department of Biosystems Science and Engineering
Daniel Bojar: ETH Zürich, Department of Biosystems Science and Engineering
Giorgio Rizzi: Biozentrum, University of Basel
Ghislaine Charpin-El Hamri: Département Génie Biologique, Institut Universitaire de Technologie (IUTA)
Marie Daoud El-Baba: Département Génie Biologique, Institut Universitaire de Technologie (IUTA)
Pratik Saxena: ETH Zürich, Department of Biosystems Science and Engineering
Simon Ausländer: ETH Zürich, Department of Biosystems Science and Engineering
Kelly R. Tan: Biozentrum, University of Basel
Martin Fussenegger: ETH Zürich, Department of Biosystems Science and Engineering

DOI: https://doi.org/10.1038/s41467-018-03733-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Exosomes function as intercellular information transmitters and are candidates for delivery of therapeutic agents. Here the authors present EXOtic, a synthetic biology device for in-situ production of designer exosomes and demonstrate in vivo application in models of Parkinson's disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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