Functional recovery following hospitalisation of patients diagnosed with COVID-19: a protocol for a longitudinal cohort study
Julie C Reid,
Maureen Markle-Reid,
Ameen Patel,
Andrew P Costa,
Maura Marcucci,
MyLinh Duong,
Connie Schumacher,
Aaron Jones,
Mats Junek,
Marla K Beauchamp,
Parminder Raina,
Lauren E Griffith,
Sophie Corriveau,
Shariq Haider,
Terence Ho,
Rebecca Kruisselbrink,
Hope Morrison,
Natya Raghavan,
Leslie Martin,
Carla Girolametto
Affiliations
Julie C Reid
Department of Health Research Methods, Evidence, and Impact, McMaster University Medical Centre, Hamilton, Ontario, Canada
Maureen Markle-Reid
2 School of Nursing, Aging, Community and Health Research Unit, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
Ameen Patel
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Andrew P Costa
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada
Maura Marcucci
Departments of Health Research Methods, Evidence, and Impact, and Medicine, Division of Perioperative Care and Department of Medicine, Division of General Internal Medicine, McMaster University, Hamilton, Ontario, Canada
MyLinh Duong
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Connie Schumacher
Department of Nursing, Brock University, St. Catharines, Ontario, Canada
Aaron Jones
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada
Mats Junek
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Marla K Beauchamp
School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Parminder Raina
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada
Lauren E Griffith
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada
Sophie Corriveau
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Shariq Haider
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Terence Ho
Firestone Institute for Respiratory Health, St. Joseph`s Healthcare Hamilton, Hamilton, Ontario, Canada
Rebecca Kruisselbrink
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Hope Morrison
School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada
Natya Raghavan
Firestone Institute for Respiratory Health, St. Joseph`s Healthcare Hamilton, Hamilton, Ontario, Canada
Leslie Martin
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Carla Girolametto
Department of Research, Innovation, and Clinical Trials, Grand River Hospital, Kitchener, Ontario, Canada
Introduction COVID-19 is an international public health crisis with more than 132 million infections worldwide. Beyond acute infection, emerging data indicate patients diagnosed with COVID-19 may experience persistent sequelae similar to survivors of sepsis or acute respiratory syndromes, including mobility limitations and fatigue. However, there is limited evidence on the trajectory of functional recovery in those hospitalised with COVID-19. The primary aim of the Coronavirus Registry Functional Recovery (COREG-FR) study is to understand the trajectory of functional recovery among individuals hospitalised for COVID-19 over the medium (up to 6 months) and longer term (6–12 months) that will guide clinical care and optimal management of serious COVID-19 illness and recovery.Methods and analysis COREG-FR is a multicentre longitudinal cohort study. We will enrol a minimum of 211 adults age 18 years and older with COVID-19 from five hospitals. Participants will be followed from admission to hospital as an inpatient, to hospital discharge, and at 3-month, 6-month, 9-month and up to 12-month post-hospital discharge. We will conduct telephone interviews at ward admission and discharge, and telephone interviews plus in-person assessments of physical function and lung function at all remaining follow-ups. Our primary outcome is the Activity Measure for Post-Acute Care mobility scale measured at all time points. We will conduct linear mixed effects regression analyses to explore determinants of functional outcomes after COVID-19 illness. Subgroup analyses based on age (≤65 vs >65 years), frailty status (Clinical Frailty Scale score ≤4 vs >5) and variants of concern will be conducted.Ethics and dissemination COREG-FR has been approved by Research Ethics Boards at participating sites. We will disseminate this work through peer-reviewed manuscripts, presentations at national and international meetings and through the established COREG website (www.coregontario.ca). COREG-FR is designed as a data platform for future studies evaluating COVID-19 recovery.Trial registration number NCT04602260; Pre-results.
