Novel CD123×CD33 bicistronic chimeric antigen receptor (CAR)‐T therapy has potential to reduce escape from single‐target CAR‐T with no more hematotoxicity

• Zhenzhen Wang,
• Yang Lu,
• Yu Liu,
• Junli Mou,
• Xiaoyu Liu,
• Manling Chen,
• Ying Wang,
• Yingxi Xu,
• Qing Rao,
• Haiyan Xing,
• Kejing Tang,
• Zheng Tian,
• Bing Wang,
• Wei Qi,
• Min Wang,
• Shaowei Qiu,
• Dongsheng Xiong,
• Jianxiang Wang

Affiliations

Zhenzhen Wang

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Yang Lu

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Yu Liu

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Junli Mou

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Xiaoyu Liu

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Manling Chen

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Ying Wang

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Yingxi Xu

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Qing Rao

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Haiyan Xing

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Kejing Tang

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Zheng Tian

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Bing Wang

Novogene Co, Ltd BeijingP. R. China

Wei Qi

Novogene Co, Ltd BeijingP. R. China

Min Wang

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Shaowei Qiu

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Dongsheng Xiong

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China

Jianxiang Wang

State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Tianjin Key Laboratory of Cell Therapy for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College TianjinP. R. China