Predicting disease course in ulcerative colitis using stool proteins identified through an aptamer-based screen

Sanam Soomro; Suresh Venkateswaran; Kamala Vanarsa; Marwa Kharboutli; Malavika Nidhi; Ramya Susarla; Ting Zhang; Prashanth Sasidharan; Kyung Hyun Lee; Joel Rosh; James Markowitz; Claudia Pedroza; Lee A. Denson; Jeffrey Hyams; Subra Kugathasan; Chandra Mohan

doi:10.1038/s41467-021-24235-0

Nature Communications (Jun 2021)

Predicting disease course in ulcerative colitis using stool proteins identified through an aptamer-based screen

Sanam Soomro,
Suresh Venkateswaran,
Kamala Vanarsa,
Marwa Kharboutli,
Malavika Nidhi,
Ramya Susarla,
Ting Zhang,
Prashanth Sasidharan,
Kyung Hyun Lee,
Joel Rosh,
James Markowitz,
Claudia Pedroza,
Lee A. Denson,
Jeffrey Hyams,
Subra Kugathasan,
Chandra Mohan

Affiliations

Sanam Soomro: Department Biomedical Engineering, University of Houston
Suresh Venkateswaran: Department of Pediatrics, Emory University School of Medicine and Children Health Care of Atlanta
Kamala Vanarsa: Department Biomedical Engineering, University of Houston
Marwa Kharboutli: Department Biomedical Engineering, University of Houston
Malavika Nidhi: Department Biomedical Engineering, University of Houston
Ramya Susarla: Department Biomedical Engineering, University of Houston
Ting Zhang: Department Biomedical Engineering, University of Houston
Prashanth Sasidharan: Department Biomedical Engineering, University of Houston
Kyung Hyun Lee: Center for Clinical Research and Evidence-based Medicine, McGovern Medical School, UT Health Science Center at Houston
Joel Rosh: Division of Gastroenterology, Hepatology, and Nutrition, Goryeb Children’s Hospital, Atlantic Health
James Markowitz: Division of Gastroenterology, Hepatology, and Nutrition, Cohen Children’s Medical Center Of New York
Claudia Pedroza: Center for Clinical Research and Evidence-based Medicine, McGovern Medical School, UT Health Science Center at Houston
Lee A. Denson: Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine
Jeffrey Hyams: Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children’s Medical Center
Subra Kugathasan: Department of Pediatrics, Emory University School of Medicine and Children Health Care of Atlanta
Chandra Mohan: Department Biomedical Engineering, University of Houston

DOI: https://doi.org/10.1038/s41467-021-24235-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Stool biomarkers hold promise for monitoring disease activity and predicting clinical course in inflammatory bowel disease (IBD) as they originate from the inflamed tissue. Here the authors report an aptamer-based proteomic screen, and discover several stool proteins that predict remission at four weeks.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal