Nature Communications (Oct 2022)

Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer

  • Juan-Juan Li,
  • Yuqing Hu,
  • Bing Hu,
  • Wenbo Wang,
  • Haiqi Xu,
  • Xin-Yue Hu,
  • Fei Ding,
  • Hua-Bin Li,
  • Ke-Rang Wang,
  • Xinge Zhang,
  • Dong-Sheng Guo

DOI
https://doi.org/10.1038/s41467-022-33920-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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Infection is a major issue in chronic diabetic wounds. Here, the authors report on a hypoxia triggered drug delivery system to achieve higher drug levels with controlled release to treat wounds infected with multidrug-resistant pseudomonas aeruginosa and demonstrate antibacterial and anti-biofilm action