Nature Communications (Sep 2020)
Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction
- Jacqueline Saw,
- Min-Lee Yang,
- Mark Trinder,
- Catherine Tcheandjieu,
- Chang Xu,
- Andrew Starovoytov,
- Isabelle Birt,
- Michael R. Mathis,
- Kristina L. Hunker,
- Ellen M. Schmidt,
- Linda Jackson,
- Natalia Fendrikova-Mahlay,
- Matthew Zawistowski,
- Chad M. Brummett,
- Sebastian Zoellner,
- Alexander Katz,
- Dawn M. Coleman,
- Kirby Swan,
- Christopher J. O’Donnell,
- Million Veteran Program,
- Xiang Zhou,
- Jun Z. Li,
- Heather L. Gornik,
- Themistocles L. Assimes,
- James C. Stanley,
- Liam R. Brunham,
- Santhi K. Ganesh
Affiliations
- Jacqueline Saw
- Vancouver General Hospital, Division of Cardiology, University of British Columbia
- Min-Lee Yang
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- Mark Trinder
- Vancouver General Hospital, Division of Cardiology, University of British Columbia
- Catherine Tcheandjieu
- VA Palo Alto Health Care System
- Chang Xu
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Andrew Starovoytov
- Vancouver General Hospital, Division of Cardiology, University of British Columbia
- Isabelle Birt
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- Michael R. Mathis
- Department of Anesthesiology, Michigan Medicine, University of Michigan
- Kristina L. Hunker
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- Ellen M. Schmidt
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Linda Jackson
- Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia
- Natalia Fendrikova-Mahlay
- Heart and Vascular Institute, Cleveland Clinic
- Matthew Zawistowski
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Chad M. Brummett
- Department of Anesthesiology, Michigan Medicine, University of Michigan
- Sebastian Zoellner
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Alexander Katz
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- Dawn M. Coleman
- Vascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan
- Kirby Swan
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- Christopher J. O’Donnell
- VA Boston Healthcare System
- Million Veteran Program
- Xiang Zhou
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Jun Z. Li
- Department of Human Genetics, University of Michigan Medical School
- Heather L. Gornik
- Heart and Vascular Institute, Cleveland Clinic
- Themistocles L. Assimes
- VA Palo Alto Health Care System
- James C. Stanley
- Vascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan
- Liam R. Brunham
- Vancouver General Hospital, Division of Cardiology, University of British Columbia
- Santhi K. Ganesh
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- DOI
- https://doi.org/10.1038/s41467-020-17558-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Spontaneous coronary artery dissection (SCAD) is a cause of myocardial infarction Here, the authors present a genome-wide association study of SCAD, finding an association at 1q21.2 which potentially affects expression of ADAMTSL4.
