MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair

Xiao-Wen Yang; Xiao-Peng Han; Chong Han; James London; Richard Fishel; Jiaquan Liu

doi:10.1038/s41467-022-33479-3

Nature Communications (Oct 2022)

MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair

Xiao-Wen Yang,
Xiao-Peng Han,
Chong Han,
James London,
Richard Fishel,
Jiaquan Liu

Affiliations

Xiao-Wen Yang: State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Xiao-Peng Han: State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Chong Han: State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
James London: Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Center
Richard Fishel: Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Center
Jiaquan Liu: State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-33479-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

MutS and MutL homologs are thought to form a stable complex to execute mismatch repair. This work shows that E. coli MutS only acts as a mismatch-dependent clamp-loader that assembles the MutL sliding clamp.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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