Condições de estabilidade para preparações magistrais contendo clorexidina

Abstract

The mouthwash containing chlorhexidine (CHX) is a solution and aims to complement the oral hygiene. It is considered standard for judging of antimicrobial effectiveness compared to other chemical agents in dentistry. CHX used in low concentrations it has a bacteriostatic and bactericidal high. The mouthwash consisting of CHX has some side effects, including blackening of the teeth, tongue and resets, burning mouth and changes in taste and to reverse the process, no need of stopping treatment. There are several factors that may interfere with the stability of CHX, including pH, light, and presence of substances with anionic character in the composition and packing in containers inadequate. His prolonged substantivity accounts for their effectiveness, with a view that can be retained in the oral cavity for up to 12 hours. CHX has been considered an antimicrobial agent is extremely important to present many advantages, among them non-toxic and safety in addition to presenting properties fungicide, algicide and virucidal. The validity of a extemporaneous preparation containing CHX may be estimated at about six months, provided that all the conditions of stability of the active substance, among which stand out the pH of the final product should be between 5.5 and 7.0 avoiding chemical incompatibilities with other components of the solution, and the packing in plastic amber PET. Finally, it is suggested that extemporaneous solutions containing CHX can be effective in treating periodontal diseases, since the conditions for stability, packaging and storage.

Keywords

• Chlorhexidine
• Stability
• Mouthwashes.