Nature Communications (Aug 2018)
EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
- Li Wang,
- Abdel Saci,
- Peter M. Szabo,
- Scott D. Chasalow,
- Mireia Castillo-Martin,
- Josep Domingo-Domenech,
- Arlene Siefker-Radtke,
- Padmanee Sharma,
- John P. Sfakianos,
- Yixuan Gong,
- Ana Dominguez-Andres,
- William K. Oh,
- David Mulholland,
- Alex Azrilevich,
- Liangyuan Hu,
- Carlos Cordon-Cardo,
- Hélène Salmon,
- Nina Bhardwaj,
- Jun Zhu,
- Matthew D. Galsky
Affiliations
- Li Wang
- Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Abdel Saci
- Bristol-Myers Squibb
- Peter M. Szabo
- Bristol-Myers Squibb
- Scott D. Chasalow
- Bristol-Myers Squibb
- Mireia Castillo-Martin
- Department of Pathology, Icahn School of Medicine at Mount Sinai
- Josep Domingo-Domenech
- Departments of Oncology and Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University
- Arlene Siefker-Radtke
- Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center
- Padmanee Sharma
- Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center
- John P. Sfakianos
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Yixuan Gong
- Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute
- Ana Dominguez-Andres
- Departments of Oncology and Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University
- William K. Oh
- Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute
- David Mulholland
- Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute
- Alex Azrilevich
- Bristol-Myers Squibb
- Liangyuan Hu
- Department of Population Health Science and Policy, Center for Biostatistics, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute
- Carlos Cordon-Cardo
- Department of Pathology, Icahn School of Medicine at Mount Sinai
- Hélène Salmon
- Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute
- Nina Bhardwaj
- Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute
- Jun Zhu
- Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Matthew D. Galsky
- Department of Medicine, Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-018-05992-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Although T-cell infiltration is correlated with EMT-related gene expression in urothelial cancer specimens, here, the authors report EMT-related signatures in urothelial cancer arise mainly from stromal cells. Increased EMT-related gene expression in T-cell infiltrated tumors is associated with an attenuated response to immune checkpoint blockade, providing a rationale for therapeutic co-targeting PD-1 and stromal elements.
