Nature Communications (Dec 2017)
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
- Gregory Segala,
- Marion David,
- Philippe de Medina,
- Mathias C. Poirot,
- Nizar Serhan,
- François Vergez,
- Aurelie Mougel,
- Estelle Saland,
- Kevin Carayon,
- Julie Leignadier,
- Nicolas Caron,
- Maud Voisin,
- Julia Cherier,
- Laetitia Ligat,
- Frederic Lopez,
- Emmanuel Noguer,
- Arnaud Rives,
- Bruno Payré,
- Talal al Saati,
- Antonin Lamaziere,
- Gaëtan Despres,
- Jean-Marc Lobaccaro,
- Silvere Baron,
- Cecile Demur,
- Fabienne de Toni,
- Clément Larrue,
- Helena Boutzen,
- Fabienne Thomas,
- Jean-Emmanuel Sarry,
- Marie Tosolini,
- Didier Picard,
- Michel Record,
- Christian Récher,
- Marc Poirot,
- Sandrine Silvente-Poirot
Affiliations
- Gregory Segala
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Marion David
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Philippe de Medina
- AFFICHEM
- Mathias C. Poirot
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Nizar Serhan
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- François Vergez
- Service d’Hématologie, Institut Universitaire du Cancer de Toulouse-Oncopole, CHU de Toulouse
- Aurelie Mougel
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Estelle Saland
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Chemoresistance, Stem Cells and Metabolism in Acute Myeloid Leukemia
- Kevin Carayon
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Julie Leignadier
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Nicolas Caron
- AFFICHEM
- Maud Voisin
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Julia Cherier
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Laetitia Ligat
- UMR 1037-CRCT, Pole Technologique
- Frederic Lopez
- UMR 1037-CRCT, Pole Technologique
- Emmanuel Noguer
- AFFICHEM
- Arnaud Rives
- AFFICHEM
- Bruno Payré
- Centre de Microscopie Electronique Appliquée à la Biologie
- Talal al Saati
- INSERM-US006 ANEXPLO/CREFRE F-31024
- Antonin Lamaziere
- Laboratory of Mass Spectrometry, INSERM ERL 1157, CNRS UMR 7203 LBM, Sorbonne Universités-UPMC, CHU Saint-Antoine
- Gaëtan Despres
- Laboratory of Mass Spectrometry, INSERM ERL 1157, CNRS UMR 7203 LBM, Sorbonne Universités-UPMC, CHU Saint-Antoine
- Jean-Marc Lobaccaro
- Université de Clermont Auvergne, CNRS, INSERM, GReD
- Silvere Baron
- Université de Clermont Auvergne, CNRS, INSERM, GReD
- Cecile Demur
- Service d’Hématologie, Institut Universitaire du Cancer de Toulouse-Oncopole, CHU de Toulouse
- Fabienne de Toni
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Chemoresistance, Stem Cells and Metabolism in Acute Myeloid Leukemia
- Clément Larrue
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Chemoresistance, Stem Cells and Metabolism in Acute Myeloid Leukemia
- Helena Boutzen
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Chemoresistance, Stem Cells and Metabolism in Acute Myeloid Leukemia
- Fabienne Thomas
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Dose Individualisation of Anticancer Drugs Team
- Jean-Emmanuel Sarry
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Chemoresistance, Stem Cells and Metabolism in Acute Myeloid Leukemia
- Marie Tosolini
- UMR 1037-CRCT, Pole Technologique
- Didier Picard
- Département de Biologie Cellulaire, Université de Genève
- Michel Record
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Christian Récher
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Chemoresistance, Stem Cells and Metabolism in Acute Myeloid Leukemia
- Marc Poirot
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- Sandrine Silvente-Poirot
- UMR 1037-CRCT, Université de Toulouse, INSERM, UPS, Cholesterol Metabolism and Therapeutic Innovations Team
- DOI
- https://doi.org/10.1038/s41467-017-01948-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.
