Daily functioning in glioma survivors: associations with cognitive function, psychological factors and quality of life
Kathleen Van Dyk,
Lucy Wall,
Brandon F Heimberg,
Justin Choi,
Catalina Raymond,
Chencai Wang,
Albert Lai,
Timothy F Cloughesy,
Benjamin M Ellingson,
Phioanh Nghiemphu
Affiliations
Kathleen Van Dyk
1Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA
Lucy Wall
1Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA
Brandon F Heimberg
1Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA
Justin Choi
3Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
Catalina Raymond
4UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision & Imaging Biomarkers, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
Chencai Wang
4UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision & Imaging Biomarkers, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
Albert Lai
2Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90024, USA
Timothy F Cloughesy
2Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90024, USA
Benjamin M Ellingson
1Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA
Phioanh Nghiemphu
2Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90024, USA
Aim: Understanding and supporting quality of life (QoL) and daily functioning in glioma patients is a clinical imperative. In this study, we examined the relationship between cognition, psychological factors, measures of health-related QoL and functioning in glioma survivors. Materials & methods: We examined neuropsychological, self-reported cognition, mood and QoL correlates of work and non-work-related daily functioning in 23 glioma survivors, and carried out linear models of the best predictors. Results & conclusion: A total of 13/23 participants were working at the time of enrollment. The best model for worse work-related functioning (R2 = .83) included worse self-reported cognitive function, depression, loneliness and brain tumor symptoms. The best model for worse non-work-related functioning (R2 = .61) included worse self-reported cognitive functioning, anxiety, sleep disturbance and physical functioning. Neuropsychological variables were not among the most highly correlated with function. Worse cognitive, particularly self-reported and psychosocial outcomes may compromise optimal functioning in glioma survivors.
