Nature Communications (Jul 2020)
Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation
- Chrispin Chaguza,
- Madikay Senghore,
- Ebrima Bojang,
- Rebecca A. Gladstone,
- Stephanie W. Lo,
- Peggy-Estelle Tientcheu,
- Rowan E. Bancroft,
- Archibald Worwui,
- Ebenezer Foster-Nyarko,
- Fatima Ceesay,
- Catherine Okoi,
- Lesley McGee,
- Keith P. Klugman,
- Robert F. Breiman,
- Michael R. Barer,
- Richard A. Adegbola,
- Martin Antonio,
- Stephen D. Bentley,
- Brenda A. Kwambana-Adams
Affiliations
- Chrispin Chaguza
- Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus
- Madikay Senghore
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Ebrima Bojang
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Rebecca A. Gladstone
- Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus
- Stephanie W. Lo
- Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus
- Peggy-Estelle Tientcheu
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Rowan E. Bancroft
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Archibald Worwui
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Ebenezer Foster-Nyarko
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Fatima Ceesay
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Catherine Okoi
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Lesley McGee
- Respiratory Diseases Branch, Centers for Disease Control and Prevention
- Keith P. Klugman
- Hubert Department of Global Health, Rollins School of Public Health, Emory University
- Robert F. Breiman
- Emory Global Health Institute, Emory University
- Michael R. Barer
- Department of Infection, Immunity and Inflammation, University of Leicester
- Richard A. Adegbola
- RAMBICON Immunisation & Global Health Consulting, 6A Platinum Close
- Martin Antonio
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Stephen D. Bentley
- Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus
- Brenda A. Kwambana-Adams
- Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine
- DOI
- https://doi.org/10.1038/s41467-020-17327-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleotide substitution rates and intra-host homologous recombination.
