Nature Communications (Oct 2019)

Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus

  • Katy Poncin,
  • Agnès Roba,
  • Ravikumar Jimmidi,
  • Georges Potemberg,
  • Antonella Fioravanti,
  • Nayla Francis,
  • Kévin Willemart,
  • Nicolas Zeippen,
  • Arnaud Machelart,
  • Emanuele G. Biondi,
  • Eric Muraille,
  • Stéphane P. Vincent,
  • Xavier De Bolle

DOI
https://doi.org/10.1038/s41467-019-12516-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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It is assumed that intracellular pathogenic bacteria must cope with DNA alkylating stress within host cells. Here, Poncin et al. show that the pathogen Brucella abortus does encounter alkylating stress within macrophages, and shed light into the pathways required for DNA repair in this organism.