Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity
Wei Feng,
Yuan Zhou,
Ling-Yu Zhou,
Li-Ying Kang,
Xiang Wang,
Bao-Lin Li,
Qing Li,
Li-Ying Niu
Affiliations
Wei Feng
School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Yuan Zhou
School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Ling-Yu Zhou
School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Li-Ying Kang
School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Xiang Wang
School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Bao-Lin Li
School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Qing Li
School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Li-Ying Niu
School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A–E (1–5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1–5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC50 ranging from 5.9 to 33.9 μM compared to Cisplatin.