Nature Communications (Nov 2020)
FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
- Weiwei Liang,
- Xinjian Peng,
- Qingqing Li,
- Pingzhang Wang,
- Ping Lv,
- Quansheng Song,
- Shaoping She,
- Shiyang Huang,
- Keqiang Chen,
- Wanghua Gong,
- Wuxing Yuan,
- Vishal Thovarai,
- Teizo Yoshimura,
- Colm O’huigin,
- Giorgio Trinchieri,
- Jiaqiang Huang,
- Shuye Lin,
- Xiaohong Yao,
- Xiuwu Bian,
- Wei Kong,
- Jianzhong Xi,
- Ji Ming Wang,
- Ying Wang
Affiliations
- Weiwei Liang
- Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University
- Xinjian Peng
- Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University
- Qingqing Li
- Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University
- Pingzhang Wang
- Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University
- Ping Lv
- Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University
- Quansheng Song
- Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University
- Shaoping She
- Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University
- Shiyang Huang
- Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University
- Keqiang Chen
- Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick
- Wanghua Gong
- Basic Research Program, Leidos Biomedical Research, Inc
- Wuxing Yuan
- Microbiome Sequencing Core, Leidos Biomedical Research, Inc
- Vishal Thovarai
- Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
- Teizo Yoshimura
- Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
- Colm O’huigin
- Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick
- Giorgio Trinchieri
- Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick
- Jiaqiang Huang
- Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick
- Shuye Lin
- Cancer Research Center, Beijing Chest Hospital affiliated to Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research Institute
- Xiaohong Yao
- Institute of Pathology, South-west Hospital and Cancer Center
- Xiuwu Bian
- Institute of Pathology, South-west Hospital and Cancer Center
- Wei Kong
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University
- Jianzhong Xi
- Department of Biomedicine, College of Engineering, Peking University
- Ji Ming Wang
- Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick
- Ying Wang
- Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University
- DOI
- https://doi.org/10.1038/s41467-020-19691-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The cytokine like protein FAM3D (Fam3D in mice) is highly expressed in the digestive tract with unknown role in colon pathophysiology. Here, by using gene deficient mice, the authors show that Fam3D is critically involved in colon homeostasis, host defense against colitis-associated carcinogenesis, and the balance of microbiota.
