Nature Communications (Jan 2022)
Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts
- Rhia Kundu,
- Janakan Sam Narean,
- Lulu Wang,
- Joseph Fenn,
- Timesh Pillay,
- Nieves Derqui Fernandez,
- Emily Conibear,
- Aleksandra Koycheva,
- Megan Davies,
- Mica Tolosa-Wright,
- Seran Hakki,
- Robert Varro,
- Eimear McDermott,
- Sarah Hammett,
- Jessica Cutajar,
- Ryan S. Thwaites,
- Eleanor Parker,
- Carolina Rosadas,
- Myra McClure,
- Richard Tedder,
- Graham P. Taylor,
- Jake Dunning,
- Ajit Lalvani
Affiliations
- Rhia Kundu
- NIHR HPRU in Respiratory Infections, Imperial College London
- Janakan Sam Narean
- NIHR HPRU in Respiratory Infections, Imperial College London
- Lulu Wang
- NIHR HPRU in Respiratory Infections, Imperial College London
- Joseph Fenn
- NIHR HPRU in Respiratory Infections, Imperial College London
- Timesh Pillay
- NIHR HPRU in Respiratory Infections, Imperial College London
- Nieves Derqui Fernandez
- NIHR HPRU in Respiratory Infections, Imperial College London
- Emily Conibear
- NIHR HPRU in Respiratory Infections, Imperial College London
- Aleksandra Koycheva
- NIHR HPRU in Respiratory Infections, Imperial College London
- Megan Davies
- NIHR HPRU in Respiratory Infections, Imperial College London
- Mica Tolosa-Wright
- NIHR HPRU in Respiratory Infections, Imperial College London
- Seran Hakki
- NIHR HPRU in Respiratory Infections, Imperial College London
- Robert Varro
- NIHR HPRU in Respiratory Infections, Imperial College London
- Eimear McDermott
- NIHR HPRU in Respiratory Infections, Imperial College London
- Sarah Hammett
- NIHR HPRU in Respiratory Infections, Imperial College London
- Jessica Cutajar
- NIHR HPRU in Respiratory Infections, Imperial College London
- Ryan S. Thwaites
- National Heart and Lung Institute, Imperial College London
- Eleanor Parker
- Section of Virology, Department of Infectious Disease, Imperial College London
- Carolina Rosadas
- Section of Virology, Department of Infectious Disease, Imperial College London
- Myra McClure
- Section of Virology, Department of Infectious Disease, Imperial College London
- Richard Tedder
- Section of Virology, Department of Infectious Disease, Imperial College London
- Graham P. Taylor
- Section of Virology, Department of Infectious Disease, Imperial College London
- Jake Dunning
- National Infection Service, Public Health England
- Ajit Lalvani
- NIHR HPRU in Respiratory Infections, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-021-27674-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 8
Abstract
While cross-reactive immunity between human coronavirus and SARS-CoV-2 may contribute to host protection, validating evidences are still scarce. Here the authors assess a cohort of 52 donors with immediate-early contact with SARS-CoV-2 to correlate higher frequency of cross-reactive T cells with lower infection rate.
