Nature Communications (Nov 2022)
A glutamine-based single α-helix scaffold to target globular proteins
- Albert Escobedo,
- Jonathan Piccirillo,
- Juan Aranda,
- Tammo Diercks,
- Borja Mateos,
- Carla Garcia-Cabau,
- Macarena Sánchez-Navarro,
- Busra Topal,
- Mateusz Biesaga,
- Lasse Staby,
- Birthe B. Kragelund,
- Jesús García,
- Oscar Millet,
- Modesto Orozco,
- Murray Coles,
- Ramon Crehuet,
- Xavier Salvatella
Affiliations
- Albert Escobedo
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Jonathan Piccirillo
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Juan Aranda
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Tammo Diercks
- CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Science and Technology Park
- Borja Mateos
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Carla Garcia-Cabau
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Macarena Sánchez-Navarro
- Department of Molecular Biology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN-CSIC)
- Busra Topal
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Mateusz Biesaga
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Lasse Staby
- REPIN and Structural Biology and NMR Laboratory, The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen
- Birthe B. Kragelund
- REPIN and Structural Biology and NMR Laboratory, The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen
- Jesús García
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Oscar Millet
- CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Science and Technology Park
- Modesto Orozco
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Murray Coles
- Department of Protein Evolution, Max Planck Institute for Biology
- Ramon Crehuet
- Institute for Advanced Chemistry of Catalonia (IQAC), CSIC
- Xavier Salvatella
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-022-34793-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Targeting biomedically relevant protein-protein interactions is a long-lasting challenge in medicinal chemistry. Here, the authors develop a single α-helical peptide scaffold that can be tailored to target globular proteins of biomedical interest.
