Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues

Dominika W. Gajdasik; Fabrina Gaspal; Emily E. Halford; Remi Fiancette; Emma E. Dutton; Claire Willis; Timo Rückert; Chiara Romagnani; Audrey Gerard; Sarah L. Bevington; Andrew S. MacDonald; Marina Botto; Timothy Vyse; David R. Withers

doi:10.1038/s41467-020-17293-3

Nature Communications (Jul 2020)

Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues

Dominika W. Gajdasik,
Fabrina Gaspal,
Emily E. Halford,
Remi Fiancette,
Emma E. Dutton,
Claire Willis,
Timo Rückert,
Chiara Romagnani,
Audrey Gerard,
Sarah L. Bevington,
Andrew S. MacDonald,
Marina Botto,
Timothy Vyse,
David R. Withers

Affiliations

Dominika W. Gajdasik: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
Fabrina Gaspal: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
Emily E. Halford: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
Remi Fiancette: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
Emma E. Dutton: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
Claire Willis: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
Timo Rückert: Med. Klinik m.S. Gastroenterologie, Infektiologie und Rheumatologie and Deutsches Rheuma-Forschungszentrum, Charité - Universitätsmedizin Berlin
Chiara Romagnani: Med. Klinik m.S. Gastroenterologie, Infektiologie und Rheumatologie and Deutsches Rheuma-Forschungszentrum, Charité - Universitätsmedizin Berlin
Audrey Gerard: The Kennedy Institute of Rheumatology, The University of Oxford
Sarah L. Bevington: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Andrew S. MacDonald: Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester
Marina Botto: Department of Medicine, Centre for Inflammatory Disease, Imperial College London
Timothy Vyse: Division of Medical and Molecular Genetics and Immunology, Infection and Inflammatory Disease, King’s College London
David R. Withers: Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham

DOI: https://doi.org/10.1038/s41467-020-17293-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

The OX40-OX40L axis is a crucial component of the costimulatory requirement of CD4 T cell responses. Here, the authors show context and cell type specific expression of OX40L for driving Th1 cell generation during acute and chronic models of infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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