Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

Dominik Hoelper; Hongda Huang; Aayushi Y. Jain; Dinshaw J. Patel; Peter W. Lewis

doi:10.1038/s41467-017-01206-y

Nature Communications (Oct 2017)

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

Dominik Hoelper,
Hongda Huang,
Aayushi Y. Jain,
Dinshaw J. Patel,
Peter W. Lewis

Affiliations

Dominik Hoelper: Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin
Hongda Huang: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
Aayushi Y. Jain: Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin
Dinshaw J. Patel: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
Peter W. Lewis: Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin

DOI: https://doi.org/10.1038/s41467-017-01206-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-independent functions of DAXX.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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