Nature Communications (Mar 2019)
ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield
- Juanjuan Ou,
- Yuan Peng,
- Weiwen Yang,
- Yue Zhang,
- Jie Hao,
- Fu Li,
- Yanrong Chen,
- Yang Zhao,
- Xiong Xie,
- Shuang Wu,
- Lin Zha,
- Xi Luo,
- Ganfeng Xie,
- Liting Wang,
- Wei Sun,
- Qi Zhou,
- Jianjun Li,
- Houjie Liang
Affiliations
- Juanjuan Ou
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Yuan Peng
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Weiwen Yang
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Yue Zhang
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Jie Hao
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Fu Li
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Yanrong Chen
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Yang Zhao
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Xiong Xie
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Shuang Wu
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Lin Zha
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Xi Luo
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Ganfeng Xie
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Liting Wang
- Biomedical Analysis Center, Army Medical University
- Wei Sun
- Biomedical Analysis Center, Army Medical University
- Qi Zhou
- Department of Oncology, Fuling Central Hospital
- Jianjun Li
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- Houjie Liang
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University
- DOI
- https://doi.org/10.1038/s41467-019-08902-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
The mechanisms underlying differential chemotherapeutic response to 5-fluorouracil are not fully known. Here, the authors show that ABDH5 regulates sensitivity to 5-fluorouracil in colorectal cancer by regulating lysosome function.
