Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae

Keisuke Obara; Taku Yoshikawa; Ryu Yamaguchi; Keiko Kuwata; Kunio Nakatsukasa; Kohei Nishimura; Takumi Kamura

doi:10.1038/s41467-022-29704-8

Nature Communications (Apr 2022)

Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae

Keisuke Obara,
Taku Yoshikawa,
Ryu Yamaguchi,
Keiko Kuwata,
Kunio Nakatsukasa,
Kohei Nishimura,
Takumi Kamura

Affiliations

Keisuke Obara: Laboratory of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku
Taku Yoshikawa: Laboratory of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku
Ryu Yamaguchi: Laboratory of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku
Keiko Kuwata: Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Furo-cho, Chikusa-ku
Kunio Nakatsukasa: Graduate School of Science, Nagoya City University
Kohei Nishimura: Laboratory of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku
Takumi Kamura: Laboratory of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku

DOI: https://doi.org/10.1038/s41467-022-29704-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Mitochondria are transported to daughter cells by myosin via an adaptor protein Mmr1 during budding in yeast. Here they show that the regulated proteolysis of Mmr1 after mitochondria inheritance is required for mitochondrial homeostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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