Nature Communications (Feb 2018)

Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae

  • Marta A. Garbacz,
  • Scott A. Lujan,
  • Adam B. Burkholder,
  • Phillip B. Cox,
  • Qiuqin Wu,
  • Zhi-Xiong Zhou,
  • James E. Haber,
  • Thomas A. Kunkel

DOI
https://doi.org/10.1038/s41467-018-03270-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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DNA polymerases δ and ε (Pols δ and ε) are thought to be responsible for lagging and leading strand synthesis, respectively. Here the authors present evidence that Pol δ contributes to the initiation of leading strand replication in budding yeast by synthesizing DNA of both strands at replication origins.