Micrometastases identification in malignant tumors

Abstract

The article reviewed literature data relating to the methods used for detection of single tumor cells in bone marrow, lymph nodes, and peripheral blood. Sensitivity of modern detection methods is analyzed. Despite advances in the development of molecular biology and cytology, until now there is no universal approach to the micrometastases identification, and existing methods optimization are recommended.

Keywords

• breast cancer
• flow cytometry
• immunohistochemistry
• micrometastases