Antioxidants (Jun 2024)

Therapeutic Potential of Plant-Derived Compounds and Plant Extracts in Rheumatoid Arthritis—Comprehensive Review

  • Mateusz Kciuk,
  • Anjali Garg,
  • Manni Rohilla,
  • Rishabh Chaudhary,
  • Sanchit Dhankhar,
  • Sachin Dhiman,
  • Seema Bansal,
  • Monika Saini,
  • Thakur Gurjeet Singh,
  • Samrat Chauhan,
  • Somdutt Mujwar,
  • Adrianna Gielecińska,
  • Renata Kontek

DOI
https://doi.org/10.3390/antiox13070775
Journal volume & issue
Vol. 13, no. 7
p. 775

Abstract

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Rheumatoid arthritis (RA) is a persistent autoimmune disorder that is characterized by joint inflammation, discomfort, and impairment. Despite the existence of several therapeutic approaches, their effectiveness is often restricted and may be linked to unfavorable side effects. Consequently, there has been growing interest in investigating naturally derived compounds as plausible therapeutic agents for RA disease. The objective of this review is to summarize the existing preclinical and clinical evidence regarding the efficacy of naturally extracted compounds and plant extracts in the treatment of RA, focusing on their anti-inflammatory, anti-oxidative, and immunomodulatory properties. Some of the problems with using natural chemicals are the uneven quality of commercially available preparations and the poor bioavailability of these compounds. Future investigations should focus on improving the formulations, conducting thorough clinical trials, and exploring different techniques to fully utilize the intrinsic potential of naturally derived chemicals in treating RA.

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