Therapeutic Potential of Plant-Derived Compounds and Plant Extracts in Rheumatoid Arthritis—Comprehensive Review
Mateusz Kciuk,
Anjali Garg,
Manni Rohilla,
Rishabh Chaudhary,
Sanchit Dhankhar,
Sachin Dhiman,
Seema Bansal,
Monika Saini,
Thakur Gurjeet Singh,
Samrat Chauhan,
Somdutt Mujwar,
Adrianna Gielecińska,
Renata Kontek
Affiliations
Mateusz Kciuk
Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha St. 12/16, 90-237 Lodz, Poland
Anjali Garg
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India
Manni Rohilla
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India
Rishabh Chaudhary
M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133206, Haryana, India
Sanchit Dhankhar
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India
Sachin Dhiman
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India
Seema Bansal
M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133206, Haryana, India
Monika Saini
Swami Vivekanand College of Pharmacy, Ram Nagar, Banur 140601, Punjab, India
Thakur Gurjeet Singh
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India
Samrat Chauhan
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India
Somdutt Mujwar
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India
Adrianna Gielecińska
Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha St. 12/16, 90-237 Lodz, Poland
Renata Kontek
Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha St. 12/16, 90-237 Lodz, Poland
Rheumatoid arthritis (RA) is a persistent autoimmune disorder that is characterized by joint inflammation, discomfort, and impairment. Despite the existence of several therapeutic approaches, their effectiveness is often restricted and may be linked to unfavorable side effects. Consequently, there has been growing interest in investigating naturally derived compounds as plausible therapeutic agents for RA disease. The objective of this review is to summarize the existing preclinical and clinical evidence regarding the efficacy of naturally extracted compounds and plant extracts in the treatment of RA, focusing on their anti-inflammatory, anti-oxidative, and immunomodulatory properties. Some of the problems with using natural chemicals are the uneven quality of commercially available preparations and the poor bioavailability of these compounds. Future investigations should focus on improving the formulations, conducting thorough clinical trials, and exploring different techniques to fully utilize the intrinsic potential of naturally derived chemicals in treating RA.