KDELR1 Is an Independent Prognostic Predictor and Correlates With Immunity in Glioma

Yifan Yuan; Yifan Yuan; Yifan Yuan; Yifan Yuan; Biao Yang; Biao Yang; Biao Yang; Biao Yang; Zengxin Qi; Zengxin Qi; Zengxin Qi; Zengxin Qi; Zhenyuan Han; Jiajun Cai; Jiajun Cai; Jiajun Cai; Jiajun Cai; Jianping Song; Jianping Song; Jianping Song; Jianping Song; Jianping Song; Jianping Song

doi:10.3389/fonc.2022.783721

Frontiers in Oncology (Jun 2022)

KDELR1 Is an Independent Prognostic Predictor and Correlates With Immunity in Glioma

Yifan Yuan,
Yifan Yuan,
Yifan Yuan,
Yifan Yuan,
Biao Yang,
Biao Yang,
Biao Yang,
Biao Yang,
Zengxin Qi,
Zengxin Qi,
Zengxin Qi,
Zengxin Qi,
Zhenyuan Han,
Jiajun Cai,
Jiajun Cai,
Jiajun Cai,
Jiajun Cai,
Jianping Song,
Jianping Song,
Jianping Song,
Jianping Song,
Jianping Song,
Jianping Song

Affiliations

Yifan Yuan: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Yifan Yuan: National Center for Neurological Disorders, Shanghai, China
Yifan Yuan: Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
Yifan Yuan: State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
Biao Yang: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Biao Yang: National Center for Neurological Disorders, Shanghai, China
Biao Yang: Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
Biao Yang: State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
Zengxin Qi: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Zengxin Qi: National Center for Neurological Disorders, Shanghai, China
Zengxin Qi: Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
Zengxin Qi: State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
Zhenyuan Han: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China
Jiajun Cai: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Jiajun Cai: National Center for Neurological Disorders, Shanghai, China
Jiajun Cai: Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
Jiajun Cai: State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
Jianping Song: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Jianping Song: National Center for Neurological Disorders, Shanghai, China
Jianping Song: Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
Jianping Song: State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China
Jianping Song: Neurosurgical Institute of Fudan University, Shanghai, China
Jianping Song: Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China

DOI: https://doi.org/10.3389/fonc.2022.783721
Journal volume & issue: Vol. 12

Abstract

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BackgroundGliomas are the most malignant central nervous system tumors. With the development of sequencing technology, more potential biomarkers related to the treatment, prognosis, and molecular classification of glioma have been identified. Here, we intend to investigate the potential biological function and clinical value of a new biomarker in glioma.MethodsKDELR1 expression data and the corresponding clinical information were downloaded from public databases and then preprocessed using R language. Correlation, Kaplan–Meier survival, and Cox regression analyses were performed to explore the clinical significance of KDELR1 in glioma patients. Furthermore, the immune infiltration and microenvironment parameters were evaluated via TIMER and CIBERSORT. Immunohistochemistry was conducted to confirm the KDELR1 expression and its correlation with immunity infiltration and prognosis.ResultsKDELR1 was upregulated in glioma samples compared with normal brain tissues, and its expression was significantly correlated with age, the World Health Organization (WHO) grade, recurrence, necrosis, microvascular proliferation, molecular classification, isocitrate dehydrogenase (IDH) mutation, and 1p/19q codeletion status. In addition, survival analysis showed that glioma patients with KDELR1 overexpression had shorter overall survival (OS) and disease-free survival times, and Cox regression analysis revealed that KDELR1 acted as an independent prognostic factor of OS in glioma patients. Gene set enrichment analysis indicated a significant enrichment of metabolism-associated pathways. KDELR1 expression was positively associated with immune infiltration (including infiltration by CD8+ T cells, CD4+ T cells, macrophages, and so on) and microenvironment parameters (including stromal, immune, and ESTIMATE scores) in gliomas. The expression of KDELR1 and its correlation with the tumor grade and prognosis were confirmed by immunohistochemistry in clinical samples (n = 119, P < 0.05).ConclusionsTaken together, these findings suggest that KDELR1 is correlated with the tumor grade, molecular classifications, and immune infiltration; highlighting that KDELR1 is a novel and promising biomarker for molecular classification, treatment, and prognostic assessment may further indicate the treating effect of immune therapy.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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