PLoS ONE (Jan 2019)

Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored.

  • Beena Elizabeth Thomas,
  • Kannan Thiruvengadam,
  • Rani S,
  • Dileep Kadam,
  • Senthanro Ovung,
  • Shrutha Sivakumar,
  • Shri Vijay Bala Yogendra Shivakumar,
  • Mandar Paradkar,
  • Nikhil Gupte,
  • Nishi Suryavanshi,
  • C K Dolla,
  • Akshay N Gupte,
  • Rewa Kohli,
  • Neeta Pradhan,
  • Gomathi Narayan Sivaramakrishnan,
  • Sanjay Gaikwad,
  • Anju Kagal,
  • Kavitha Dhanasekaran,
  • Andrea Deluca,
  • Jonathan E Golub,
  • Vidya Mave,
  • Padmapriyadarshini Chandrasekaran,
  • Amita Gupta,
  • CTRIUMPH-RePORT India Study

DOI
https://doi.org/10.1371/journal.pone.0220507
Journal volume & issue
Vol. 14, no. 7
p. e0220507

Abstract

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BackgroundMore than 20% of tuberculosis (TB) disease worldwide may be attributable to smoking and alcohol abuse. India is the second largest consumer of tobacco products, a major consumer of alcohol particularly among males, and has the highest burden of TB globally. The impact of increasing tobacco dose, relevance of alcohol misuse and past versus current or never smoking status on TB treatment outcomes remain inadequately defined.MethodsWe conducted a multi-centric prospective cohort study of newly diagnosed adult pulmonary TB patients initiated on TB treatment and followed for a minimum of 6 months to assess the impact of smoking status with or without alcohol abuse on treatment outcomes. Smokers were defined as never smokers, past smokers or current smokers. Alcohol Use Disorder Identification Test (AUDIT) scores were used to assess alcohol misuse. The association between smoking status and treatment outcomes was assessed in univariate and multivariate random effects poisson regression models.ResultsOf 455 enrolled, 129 (28%) had a history of smoking with 94 (20%) current smokers and 35 (8%) past smokers. Unfavourable treatment outcomes were significantly higher among past and current smokers as compared to never smokers. Specifically, the risk of treatment failure was significantly higher among past smokers (aIRR = 2.66, 95% CI: 1.41-4.90, p = 0.002), recurrent TB among current smokers (aIRR = 2.94, 95% CI: 1.30-6.67, p = 0.010) and death among both past (2.63, 95% CI: 1.11-6.24, p = 0.028) and current (aIRR = 2.59, 95% CI: 1.29-5.18, p = 0.007) smokers. Furthermore, the combined effect of alcohol misuse and smoking on unfavorable treatment outcomes was significantly higher among past smokers (aIRR: 4.67, 95% CI: 2.17-10.02, pConclusionPast and current smoking along with alcohol misuse have combined effects on increasing the risk of unfavourable TB treatment outcomes. Innovative interventions that can readily address both co-morbidities are urgently needed.