Cancer Management and Research (Dec 2019)
MiR-326: Promising Biomarker for Cancer
Abstract
Yao-Jie Pan,1 Jian Wan,2 Chun-Bin Wang1 1Department of Oncology, The Affiliated Yancheng Hospital of Medicine School of Southeast University, The Third People’s Hospital of Yancheng, Yancheng 224001, People’s Republic of China; 2Department of General Surgery, Center for Difficult and Complicated Abdominal Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, People’s Republic of ChinaCorrespondence: Chun-Bin WangDepartment of Oncology, The Affiliated Yancheng Hospital of Medicine School of Southeast University, The Third People’s Hospital of Yancheng, 75 Juchang Road, Yancheng, Jiangsu 224001, People’s Republic of ChinaTel +86-515-81606113Email [email protected]: MicroRNAs (miRNAs) are small non-coding and highly conserved RNAs that act in biological processes including cell proliferation, invasion, apoptosis, metabolism, signal transduction, and tumorigenesis. The previously identified miRNA-326 (miR-326) has been reported to participate in cellular apoptosis, tumor growth, cell invasion, embryonic development, immunomodulation, chemotherapy resistance, and oncogenesis. This review presents a detailed overview of what is known about the effects of miR-326 on cell invasion, metastasis, drug resistance, proliferation, apoptosis, and its involvement in signaling pathways.Keywords: MicroRNA, miR-326, tumor suppressor, cancer, metastasis, oncogene
