Nature Communications (Aug 2020)

Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis

  • Lu Han,
  • Praneet Chaturvedi,
  • Keishi Kishimoto,
  • Hiroyuki Koike,
  • Talia Nasr,
  • Kentaro Iwasawa,
  • Kirsten Giesbrecht,
  • Phillip C. Witcher,
  • Alexandra Eicher,
  • Lauren Haines,
  • Yarim Lee,
  • John M. Shannon,
  • Mitsuru Morimoto,
  • James M. Wells,
  • Takanori Takebe,
  • Aaron M. Zorn

DOI
https://doi.org/10.1038/s41467-020-17968-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The fetal murine foregut develops into visceral organs via interactions between the mesoderm and endoderm, but how is unclear. Here, the authors use single cell RNAseq to show a diversity in organ specific splanchnic mesoderm cell-types, infer a signalling network governing organogenesis and use this to differentiate human pluripotent stem cells.