Lipid and lipoprotein disturbances in coronary atherosclerosis: comparison with general populaD tion data

Abstract

The article is devoted to the diagnostics of lipid and lipoprotein disturbances in coronary atherosclerosis among Novosibirsk City males, comparing to general population. The study included 392 males aged 35-70 years. The main group consisted of 87 patients with coronary atherosclerosis, verified at coronaroangiography. The control group was a representative population sample of 305 males. Lipid and lipoprotein profiles, baseline levels of lipid peroxidation products in low-density lipoproteins (LDL), their oxidative resistance, alpha-tocopherol and retinol levels in blood and LDL, were measured. All comparisons were performed after age adjusting. Males with coronary atherosclerosis, compared to control group, demonstrated potentially atherogenic lipid and lipoprotein profile disturbances (p<0.01): significantly increased levels of total cholesterol (CH), LDL CH (+19%), triglycerides (TG) (+86%); decreased high-density lipoprotein (HDL) CH level (-41%); substantially reduced LDL oxidative resistance (-33%; p<0.001), especially for initial LDL oxidation stages (-37%), and decreased LDL levels of alpha-tocopherol and retinol (-40% and -20%, respectively; p<0.01). The results obtained demonstrate that in coronary atherosclerosis, dominant lipid and lipoprotein disturbances include not only increased CH and LDL CH levels, but also increased TG concentration, decreased HDL CH level, and interrelated low LDL oxidative resistance and lipid-soluble antioxidant LDL concentrations. The latter is an evidence of increased atherogenic oxidative LDL modification in vascular wall.

Keywords

• coronary atherosclerosis
• atherogenic disturbances
• metabolic epidemiology
• males