Nature Communications (Jun 2020)

Multi-trait analysis of rare-variant association summary statistics using MTAR

  • Lan Luo,
  • Judong Shen,
  • Hong Zhang,
  • Aparna Chhibber,
  • Devan V. Mehrotra,
  • Zheng-Zheng Tang

DOI
https://doi.org/10.1038/s41467-020-16591-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Methods to integrate association evidence across multiple traits often focus on individual common variants GWAS. Here the authors present multi-trait analysis of rare-variant associations (MTAR), a framework for joint analysis of association summary statistics between multiple rare variants and different traits.