Cardiovascular implications of modern algorithm of hypoglycemic therapy: ?Florentine hypothesis?

Abstract

The modern algorithm of hypoglycemic therapy for patients with type 2 diabetes mellitus (DM2) has been designed to effectively reach the ?target?blood glucose and HbA1c levels associated with the lowest mortality rate.The most popular scheme is combined treatment with metformin andsulfonylureasthatmakes possible the achievement of the ?target? metabolic indices in the majority of DM2 patients. However, specific cardiovascular efficiency ofthis therapy is a matter of controversy. The safest modalities of combined therapy are discussed based on the analysis of relevant epidemiological data.

Keywords

• type 2 diabetes mellitus
• algorithm of hypoglycemic therapy
• cardiovascular complications