Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids May Extend above and below Pons and Is Associated with Other Autoimmune Diseases
Brent Berry,
Stephanie Joppa,
Edward Labin,
Vikram Puram,
Kaci McCleary,
H. Brent Clark,
Flavia Nelson
Affiliations
Brent Berry
Mayo Clinic, Department of Neurology, Rochester, MN 55455, USA
Stephanie Joppa
Department of Internal Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Edward Labin
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Vikram Puram
Medical School, University of Minnesota, Minneapolis, MN 55455, USA
Kaci McCleary
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
H. Brent Clark
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Flavia Nelson
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Many autoimmune diseases can affect the central nervous system, and their varying clinical presentations often confound a straightforward diagnosis. In this report, we describe a unique presentation of CLIPPERS syndrome. To our knowledge, this is the first case to demonstrate significant supratentorial involvement with symmetric and non-confluent lesions in the medial orbitofrontal cortex; additionally, this is the second case to describe an association between diagnoses of hypothyroidism and CLIPPERS.
