Mesoscale functional connectivity in macaque visual areas
Xingya Cai,
Haoran Xu,
Chao Han,
Peichao Li,
Jiayu Wang,
Rui Zhang,
Rendong Tang,
Chen Fang,
Kun Yan,
Qianling Song,
Chen Liang,
Haidong D. Lu
Affiliations
Xingya Cai
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Haoran Xu
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Chao Han
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Peichao Li
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Jiayu Wang
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Rui Zhang
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Rendong Tang
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Chen Fang
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Kun Yan
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Qianling Song
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Chen Liang
State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Haidong D. Lu
Corresponding author.; State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19 Xin Jie Kou Wai Street, Beijing 100875, China
Studies of resting-state functional connectivity (rsFC) have provided rich insights into the structures and functions of the human brain. However, most rsFC studies have focused on large-scale brain connectivity. To explore rsFC at a finer scale, we used intrinsic signal optical imaging to image the ongoing activity of the anesthetized macaque visual cortex. Differential signals from functional domains were used to quantify network-specific fluctuations. In 30–60 min resting-state imaging, a series of coherent activation patterns were observed in all three visual areas we examined (V1, V2, and V4). These patterns matched the known functional maps (ocular dominance, orientation, color) obtained in visual stimulation conditions. These functional connectivity (FC) networks fluctuated independently over time and exhibited similar temporal characteristics. Coherent fluctuations, however, were observed from orientation FC networks in different areas and even across two hemispheres. Thus, FC in the macaque visual cortex was fully mapped both on a fine scale and over a long range. Hemodynamic signals can be used to explore mesoscale rsFC in a submillimeter resolution.
