Acta Crystallographica Section E (Jun 2014)

Buprenorphine

  • Jaroslaw Mazurek,
  • Marcel Hoffmann,
  • Anna Fernandez Casares,
  • Phillip D. Cox,
  • Mathew D. Minardi

DOI
https://doi.org/10.1107/S1600536814009672
Journal volume & issue
Vol. 70, no. 6
pp. o635 – o635

Abstract

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In the crystal structure of a semi-synthetic opioid drug buprenorphine, C29H41NO4 {systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclopropylmethyl-3-hydroxy-6-methoxy-4,5-epoxy-6,14-ethanomorphinan-7-yl]-3,3-dimethylbutan-2-ol}, the cyclopropylmethyl group is disordered over two sites with an occupancy factor of 0.611 (3) for the major component. One of the hydroxy groups is involved in intramolecular O—H...O hydrogen bond. The other hydroxy group acts as a proton donor in an intermolecular O—H...O interaction that connects molecules into a zigzag chain along the b axis.