Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability

Thuy T. M. Ngo; Jejoong Yoo; Qing Dai; Qiucen Zhang; Chuan He; Aleksei Aksimentiev; Taekjip Ha

doi:10.1038/ncomms10813

Nature Communications (Feb 2016)

Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability

Thuy T. M. Ngo,
Jejoong Yoo,
Qing Dai,
Qiucen Zhang,
Chuan He,
Aleksei Aksimentiev,
Taekjip Ha

Affiliations

Thuy T. M. Ngo: Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign
Jejoong Yoo: Department of Physics and Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign
Qing Dai: Department of Chemistry, The University of Chicago
Qiucen Zhang: Department of Physics and Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign
Chuan He: Department of Chemistry, The University of Chicago
Aleksei Aksimentiev: Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign
Taekjip Ha: Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/ncomms10813
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

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Cytosine modifications are important epigenetic markers yet their physical influence on DNA is not well understood. Here, Ngo et al. show that different alterations affect DNA flexibility, suggesting a mechanism where modifications change accessibility of nucleosome bound DNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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