Nature Communications (Nov 2018)
Molecular insights into genome-wide association studies of chronic kidney disease-defining traits
- Xiaoguang Xu,
- James M. Eales,
- Artur Akbarov,
- Hui Guo,
- Lorenz Becker,
- David Talavera,
- Fehzan Ashraf,
- Jabran Nawaz,
- Sanjeev Pramanik,
- John Bowes,
- Xiao Jiang,
- John Dormer,
- Matthew Denniff,
- Andrzej Antczak,
- Monika Szulinska,
- Ingrid Wise,
- Priscilla R. Prestes,
- Maciej Glyda,
- Pawel Bogdanski,
- Ewa Zukowska-Szczechowska,
- Carlo Berzuini,
- Adrian S. Woolf,
- Nilesh J. Samani,
- Fadi J. Charchar,
- Maciej Tomaszewski
Affiliations
- Xiaoguang Xu
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- James M. Eales
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- Artur Akbarov
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- Hui Guo
- Division of Population Health, Health Services Research and Primary Care, Faculty of Medicine, Biology and Health, University of Manchester
- Lorenz Becker
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- David Talavera
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- Fehzan Ashraf
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- Jabran Nawaz
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- Sanjeev Pramanik
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- John Bowes
- Division of Musculoskeletal and Dermatological Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- Xiao Jiang
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- John Dormer
- University Hospitals of Leicester NHS Trust
- Matthew Denniff
- Department of Cardiovascular Sciences, University of Leicester
- Andrzej Antczak
- Department of Urology and Uro-oncology, Karol Marcinkowski University of Medical Sciences
- Monika Szulinska
- Department of Internal Medicine, Metabolic Disorders and Hypertension, Karol Marcinkowski University of Medical Sciences
- Ingrid Wise
- School of Health and Life Sciences, Federation University Australia
- Priscilla R. Prestes
- School of Health and Life Sciences, Federation University Australia
- Maciej Glyda
- Department of Transplantology and General Surgery, District Public Hospital, University of Zielona Góra
- Pawel Bogdanski
- Department of Obesity and Metabolic Disorders Treatment and Clinical Dietetics, Karol Marcinkowski University of Medical Sciences
- Ewa Zukowska-Szczechowska
- Department of Health Care, Silesian Medical College
- Carlo Berzuini
- Division of Population Health, Health Services Research and Primary Care, Faculty of Medicine, Biology and Health, University of Manchester
- Adrian S. Woolf
- Department of Paediatric Nephrology, Royal Manchester Children’s Hospital, Manchester University NHS Foundation Trust
- Nilesh J. Samani
- Department of Cardiovascular Sciences, University of Leicester
- Fadi J. Charchar
- Department of Cardiovascular Sciences, University of Leicester
- Maciej Tomaszewski
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester
- DOI
- https://doi.org/10.1038/s41467-018-07260-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
The molecular mechanisms that underlie associations in GWAS, incl. chronic kidney disease (CKD), are largely unknown. Here, the authors perform an integrative analysis of genetic, transcriptomic and epigenomic data from human kidney to pinpoint plausible molecular pathways of CKD genetic associations.
