The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapy

Zheng Shuohan; Jiang Xiaobo; Huang Sijuan; Yang Xin; Cai Wenpei; Li Binghuan; He Shumeng; Li Hua; Chen Ming

doi:10.1051/vcm/2023003

Visualized Cancer Medicine (Jan 2023)

The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapy

Zheng Shuohan,
Jiang Xiaobo,
Huang Sijuan,
Yang Xin,
Cai Wenpei,
Li Binghuan,
He Shumeng,
Li Hua,
Chen Ming

Affiliations

Zheng Shuohan: Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Jiang Xiaobo: Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Huang Sijuan: Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Yang Xin: Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Cai Wenpei: Shenzhen United Imaging Research Institute of Innovative Medical Equipment
Li Binghuan: Shanghai United Imaging Healthcare Co., Ltd
He Shumeng: United Imaging Research Institute of Intelligent Imaging
Li Hua: Shenzhen United Imaging Research Institute of Innovative Medical Equipment
Chen Ming: Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center

DOI: https://doi.org/10.1051/vcm/2023003
Journal volume & issue: Vol. 4
p. 7

Abstract

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Adaptive radiotherapy (ART) allows control of dosimetric impact of patient anatomical and functional variations over the treatment course, to minimize normal tissue exposure and maximize dose delivery to tumor. We present the first reported case of fan beam computed tomography (FBCT)-guided online ART for the treatment of small cell lung cancer (SCLC). A 62-year-old woman was diagnosed with histologically proven limited-stage SCLC. During definitive radiochemotherapy (50 Gy in daily fractions of 2.5 Gy), the tumor shrinkage resulted in an unexpected dose escalation to organs at risk (OAR). To correct the dose change, she received an online ART treatment session in our center with four-dimensional FBCT before the 12th fraction was delivered. The application of online ART, including imaging, recontouring and replanning, was feasible as the total treatment time was <25 min. Further research is warranted to verify the benefit of online ART in individualized treatment.

Published in Visualized Cancer Medicine

ISSN: 2740-4218 (Online)
Publisher: EDP Sciences
Country of publisher: France
LCC subjects: Medicine
Website: https://vcm.edpsciences.org/

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